APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
Not tested in other applications.
Product Note
This antibody was raised against human Claudin 3 Intracellular domain.
Predict Reactivity
Bovine, Rhesus Monkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS, 2% BSA
Preservative
0.025% ProClin 300
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
batch dependent
Antigen Species
Human
Immunogen
Synthetic peptide encompassing a sequence within the Intracellular domain of human Claudin 3. The exact sequence is proprietary.
Purification
Affinity purified by Protein A.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
claudin 3,C7orf1,CPE-R2,CPETR2,HRVP1,RVP1
Cellular Localization
Cell membrane
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
![Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933](/templates/default/js/lightbox/images/loading.gif "Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933")
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GTX639933 IHC-P Image
IHC-P analysis of human Fallopian tube (mucosa) tissue using GTX639933 Claudin 3 antibody [HMV309] HistoMAX™.
Strong membranous CLDN3 staining of epithelial cells.
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GTX639933 IHC-P Image
IHC-P analysis of human Submandibular gland tissue using GTX639933 Claudin 3 antibody [HMV309] HistoMAX™.
Strong membranous CLDN3 staining of glandular cells. CLDN3 staining is only very faint in excretory duct cells.
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GTX639933 IHC-P Image
IHC-P analysis of human Urinary bladder tissue using GTX639933 Claudin 3 antibody [HMV309] HistoMAX™.
Muscle-invasive urothelial carcinoma with strong CLDN3 positivity of tumor cells.
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REFERENCE
There are currently no references for Claudin 3 antibody [HMV309] HistoMAX™ (GTX639933). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Claudin 3 antibody [HMV309] HistoMAX™ (GTX639933). Be the first to share your experience with this product.
![Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933](/upload/website/prouct_img/small/GTX639933/GTX639933_20240514_IHC-P_24051319_182.webp "Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933")
![Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933](/upload/website/prouct_img/small/GTX639933/GTX639933_20240514_IHC-P_1_24051319_998.webp "Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933")
![Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933](/upload/website/prouct_img/small/GTX639933/GTX639933_20240514_IHC-P_2_24051319_753.webp "Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933")
![Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933](/upload/website/prouct_img/normal/GTX639933/GTX639933_20240514_IHC-P_24051319_182.webp "Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933")
![Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933](/upload/website/prouct_img/normal/GTX639933/GTX639933_20240514_IHC-P_1_24051319_998.webp "Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933")
![Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933](/upload/website/prouct_img/normal/GTX639933/GTX639933_20240514_IHC-P_2_24051319_753.webp "Anti-Claudin 3 antibody [HMV309] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639933")